2-(4-Fluorophenyl)-2-propanol → HCID 10480616, compound

HRID 750840Notes

Reaction equation

HRID 750840 reaction equation
CS[C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])[C:6]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[CH:5][N:4]=1.[CH3:24][C:25]([OH:34])([CH3:33])[C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=1>>[CH3:24][C:25]([CH3:33])([O:34][C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])[C:6]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[CH:5][N:4]=1)[C:26]1[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 6377332-(4-Fluorophenyl)-2-propanolHCID 597539142-Methylthio-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

Product 1

HCID 10480616HCID 10480616, compound

Procedure

2-Methylthio-5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)pyrimidine from Reference Example 3 was reacted with α,α-dimethyl-4-fluorobenzyl alcohol according to the procedure described in Example 59 to afford 2-(α,α-dimethyl-4-fluorobenzyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine (HRf): 1H-NMR 500 MHz (CDCl3): δ 1.91 (s, 6H), 6.90-7.00 (m, 5H), 7.20-7.25 (m, 3H), 7.30 (s, 1H), 7.41-7.45 (m, 2H), 8.40 (s, 1H).

Sources & evidence

ORD record
ord-bf0a3036f4984022b5080043140a1ddd
Source dataset
uspto-grants-2008_07
Patent number
US07405221B2

Reaction notes

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