3,4-Difluorophenol → HCID 59753930, compound

HRID 750843Notes

Reaction equation

HRID 750843 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[C:8]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[CH:7][N:6]=1)(=O)=O.[F:26][C:27]1[CH:28]=[C:29]([OH:34])[CH:30]=[CH:31][C:32]=1[F:33]>>[F:26][C:27]1[CH:28]=[C:29]([O:34][C:5]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=3[Cl:18])[C:8]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)=[CH:7][N:6]=2)[CH:30]=[CH:31][C:32]=1[F:33]

Participants

3

Reactant 2

HCID 759273,4-DifluorophenolHCID 69198607HCID 69198607, compound

Product 1

HCID 59753930HCID 59753930, compound

Procedure

2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine from Reference Example 3 was reacted with 3,4-difluorophenol according to the procedure described in Example 74 to afford 2-(3,4-difluorophenyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine: HPLC/MS: m/e=463 (M++1); Rt=4.60 min; 1H-NMR 400 MHz (CDCl3): δ 7.05. (m, 3H), 7.19-7.30 (m, 6H), 7.39 (d, J=2 Hz, 1H), 8.60 (s, 1H).

Sources & evidence

ORD record
ord-28afb0489366482e9c6b56b1facd0f6b
Source dataset
uspto-grants-2008_07
Patent number
US07405221B2

Reaction notes

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