4-Methoxyphenol → HCID 59753940, compound

HRID 750845Notes

Reaction equation

HRID 750845 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[C:8]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[CH:7][N:6]=1)(=O)=O.[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=1>>[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][C:5]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=3[Cl:18])[C:8]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)=[CH:7][N:6]=2)=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 69198607HCID 69198607, compound

Product 1

HCID 59753940HCID 59753940, compound

Procedure

2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine from Reference Example 3 was reacted with 4-methoxyphenol according to the procedure described in Example 74 to afford 2-(4-methoxyphenyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine: HPLC/MS: m/e=457 (M++1); Rt=4.50 min; 1H-NMR 500 MHz (CDCl3): δ 3.85 (s, 3H), 6.95 (d, J=9 Hz, 2H), 7.05. (d, J=9 Hz, 2H), 7.21 (d, J=9 Hz, 2H), 7.25-7.30 (m, 4H), 7.39 (d, J=2 Hz, 1H), 8.60 (s, 1H).

Sources & evidence

ORD record
ord-24c22b368ddb4b2eb7fc2ec9b0482d3c
Source dataset
uspto-grants-2008_07
Patent number
US07405221B2

Reaction notes

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