3-Hydroxy-5-chloropyridine → HCID 10434516, compound

Participants

Reaction Steps

2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine from Reference Example 3 was reacted with 5-chloro-3-hydroxypyridine according to the procedure described in Example 74 to afford 2-(5-chloro-3-pyridyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine: HPLC/MS: m/e=462 (M++1); Rt=4.40 min; 1H-NMR 400 MHz (CDCl3): δ 7.05. (d, J=9 Hz, 2H), 7.21 (d, J=10 Hz, 1H), 7.25-7.31 (m, 3H), 7.41 (s, 1H), 7.75 (s, 1H), 8.50 (s, 1H), 8.55 (s, 1H), 8.62 (s, 1H).

Provenance & Evidence