1-Pentanol → HCID 59753897, compound

Participants

Reaction Steps

2-Methylsulfonyl-4-(3-pyridyloxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine from Example 86 (30 mg, 0.06 mmol) was reacted with 2 equivalents each of n-butyl lithium and n-pentanol by the procedure described in Reference Examples 6 and 7 to afford the title compound: HPLC/MS: m/e=514 (M++1); Rt'4.48 min. 1H-NMR 400 MHz (CDCl3): δ 0.89-0.91 (t, 3H), 1.26-1.40 (m, 4H), 1.69-1.76 (m, 2H), 4.19-4.22 (t, 2H), 7.15-7.28 (m, 6H), 7.35 (d, J=2 Hz, 1H), 7.40-7.43 (m, 1H), 7.58-7.61 (m, 1H), 8.52-8.55 (m, 2H).

Provenance & Evidence