Isobutanol → HCID 59753953, compound

Participants

Reaction Steps

2-Methylsulfonyl-4-(3,4-difluorophenoxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine from Example 20 (65 mg, 0.12 mmol) was reacted with 2 equivalents each of n-butyl lithium and isobutyl alcohol by the procedure described in Reference Example 6 and 7 to yield the title compound: HPLC/MS: m/e=535 (M++1); Rt=5.28 min. 1H-NMR 400 MHz (CDCl3): 0.97 (d, J=7 Hz, 6H), 2.07 (m, 1H), 4.01 (d, J=7 Hz, 2H), 6.90-6.94 (m, 1H), 7.05-7.10 (m, 1H), 7.12-7.28 (m, 7H), 7.34 (d, J=2 Hz, 1H).

Provenance & Evidence