Cyclopropanemethanol → HCID 59753923, compound

Participants

Reaction Steps

2-Methylsulfonyl-4-(3,4-difluorophenoxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine from Example 20 (65 mg, 0.12 mmol) was reacted with 2 equivalents each of n-butyl lithium and cyclopropylmethanol by the procedure described in Reference Example 6 and 7 to afford the title compound: HPLC/MS: m/e=533 (M++1); Rt=5.12 min. 1H-NMR 400 MHz (CDCl3): 0.56-0.61 (m, 2H), 1.23-1.30 (m, 2H), 1.57 (s, 1H), 4.01 (d, J=7 Hz, 2H), 6.90-6.94 (m, 1H), 7.04-7.10 (m, 1H), 7.12-7.28 (m, 7H), 7.35 (d, J=2 Hz, 1H).

Provenance & Evidence