Ethanol → HCID 59753935, compound

HRID 750865Notes

Reaction equation

HRID 750865 reaction equation
CS([C:5]1[N:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[CH:13]=2)[C:8]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[C:7]([C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=2[Cl:34])[N:6]=1)(=O)=O.C([Li])CCC.[CH2:40]([OH:42])[CH3:41]>>[CH2:40]([O:42][C:5]1[N:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[CH:13]=2)[C:8]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[C:7]([C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=2[Cl:34])[N:6]=1)[CH3:41]

Participants

4

Reactant 3

HCID 702EthanolHCID 10392549HCID 10392549, compoundHCID 178418339Butyllithium

Product 1

HCID 59753935HCID 59753935, compound

Procedure

2-Methylsulfonyl-4-(3,4-difluorophenoxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine from Example 20 (30 mg, 0.06 mmol) was reacted with 2 equivalents each of n-butyl lithium and ethanol by the procedure described in Reference Example 6 and 7 to afford the title compound: HPLC/MS: m/e=507 (M++1); Rt=4.85 min. 1H-NMR 400 MHz (CDCl3): δ 1.36-1.40 (t, 3H), 4.28-4.38(dd, J=9 Hz, J=7 Hz, 2H), 6.90-6.94 (m, 1H), 7.04-7.10 (m, 1H), 7.12-7.28 (m, 7H), 7.35 (d, J=2 Hz, 1H).

Sources & evidence

ORD record
ord-17a04944dd084fd1871ad303f1b8302d
Source dataset
uspto-grants-2008_07
Patent number
US07405221B2

Reaction notes

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