Piperidine → HCID 10482581, compound

Participants

Reaction Steps

2-Methylsulfonyl-4-(3,4-difluorophenoxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine (from Example 20) (30 mg, 0.06 mmol) was reacted with excess piperidine (0.5 mL) in THF in a sealed tube at 60° C. overnight by general procedure described in Example 103 to afford the title compound: HPLC/MS: m/e=546 (M++1); Rt=5.36 min. 1H-NMR 400 MHz (CDCl3); δ 0.85-0.95 (m, 2H), 1.71-1.59 (m, 2H), 1.60-1.69 (m, 2H), 3.55-3.65 (s, 4H), 6.89-6.94 (m, 1H), 7.08-7.21 (m, 8H), 7.35 (d, J=2 Hz, 1H).

Provenance & Evidence