Dimethylamine → HCID 11755938, compound

Participants

Reaction Steps

2-Methylsulfonyl-4-(3,4-difluorophenoxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine (from Example 20) (100 mg, 0.19 mmol) was reacted with excess dimethylamine (0.14 mL, 0.28 mmol) in THF in a sealed tube at 60° C. overnight by general procedure described in Example 103 to afford the title compound: HPLC/MS: m/e=506 (M++1); Rt=4.99 min. 1H-NMR 400 MHz (CDCl3); δ 3.00-3.20 (s, 6H), 6.89-6.94 (m, 1H), 7.08-7.21 (m, 8H), 7.35 (d, J=2 Hz, 1H).

Provenance & Evidence