3-Hydroxypyridine → HCID 10074610, compound

Participants

Reaction Steps

2-(N-pyrrolidinyl)-4-methylsulfonyl-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine (HRf product from Example 36, Step A (50 mg, 0.10 mmol) was reacted with 2 equivalents each of n-butyl lithium and 3-hydroxypyridine by the procedure described in Reference Example 6 and 7 to afford the title compound: HPLC/MS: m/e=497 (M++1); Rt=3.84 min. 1H-NMR 400 MHz (CDCl3): δ 1.91-2.00 (m, 4H), 3.23-3.35 (s, 2H), 3.55-3.62 (s, 2H), 7.08-7.21 (m, 6H), 7.35-7.39 (m, 2H), 7.56-7.58 (m, 1H), 8.48 (d, J=6 Hz, 1H), 8.58 (s, 1H).

Provenance & Evidence