2,4-Bis(methylsulfonyl)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine → 2-Methylsulfonyl-4-(2-pyridyloxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine

Participants

Reaction Steps

2,4-Bis(methylsulfonyl)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine from Reference Example 5 (200 mg, 0.41 mmol) was reacted with 1.0 equivalent of n-butyl lithium and 1.1 equivalent of 2-hydroxypyridine by the procedure described in Example 86 to afford the title compound: 1H-NMR 400 MHz (CDCl3): δ 3.22 (s, 3H), 7.15-7.33 (m, 8H), 7.38 (d, J=2 Hz, 1H), 7.85-7.90 (m, 1H), 8.30-8.42 (m, 1H).

Provenance & Evidence