Pyrrolidine → 2-(2-Pyrrolidinyl)-4-(2-pyridyloxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine

Participants

Reaction Steps

2-Methylsulfonyl-4-(2-pyridyloxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine from Example 109 (45 mg, 0.09 mmol) was reacted with excess pyrrolidine (0.5 mL) in THF at a sealed tube 60° C. for overnight by general procedure Example 103 to afford the title compound: HPLC/MS: m/e=497 (M++1); Rt4.21 min. 1H-NMR 400 MHz (CDCl3): δ 1.85-1.95 (s 4H), 3.20-3.60 (m, 4H), 7.00-7.19 (m, 8H), 7.31 (d, J=2 Hz, 1H), 7.75-7.80 (m, 1H), 8.38 (m, 1H).

Provenance & Evidence