Sodium hydride → HCID 59753946, compound

Participants

Reaction Steps

2-(Methylsulfonyl)-4-ethoxy-5-(4-chlorophenyl)-6-(2,4-dichloro-phenyl)pyrimidine (LRf from Example 123) was reacted with 2 equivalents each of sodium hydride and 3,4-difluorobenzyl alcohol by the procedure described in Example 16 to afford the title compound: HPLC/MS: m/e=521 (M++1); Rt=4.90 min. 1H-NMR 400 MHz (CDCl3): δ 1.35 (t, 3H), 4.45-4.55 (dd, J=9 Hz, J=7 Hz, 2H), 5.20 (s, 2H), 7.02-7.21 (m, 9H), 7.35 (d, J=2 Hz, 1H).

Provenance & Evidence