Sodium hydride → HCID 59753911, compound

Participants

Reaction Steps

2-(Methylsulfonyl)-4-isopropyloxy-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine (LRf from Example 126) was reacted with 2 equivalents each of sodium hydride and 3,4-difluorobenzyl alcohol by the procedure described in Example 16 to afford the title compound: HPLC/MS: m/e=535 (M++1); Rt=4.99 min. 1H-NMR 500 MHz (CDCl3): δ 1.45 (d, J=8 Hz, 6H), 5.28-5.35 (m, 1H), 5.22 (s, 2H), 7.02-7.21 (m, 9H), 7.35 (d, J=2 Hz, 1H).

Provenance & Evidence