Pyrrolidine → HCID 10482582, compound

Participants

Reaction Steps

2-(3,4-Difluorobenzyloxy)-4-(methylsulfonyl)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-pyrimidine (Reference Example 7) (30 mg, 0.05 mmol) was reacted with pyrrolidine (37.7 mg, 0.53 mmol) by the same general procedure described in Example 103 to afford the title compound after flash column chromatography on silica gel (eluted with 90/10 hexanes/ethyl acetate): HPLC/MS: m/e=546 (M++1); Rt=3.70 min. 1H-NMR 400 MHz (CDCl3): δ 1.75-1.80 (br, 4H), 3.10-3.20 (br, 4H), 5.32-5.42 (m, 2H), 6.95 (d, J=9 Hz, 1H), 7.05-7.21 (m, 8H), 7.35-7.40 (m, 1H).

Provenance & Evidence