(4-Methoxyphenyl)boronic acid → HCID 59753954, compound

Participants

Reaction Steps

This derivative was prepared by the method described in Example 132 using 2-(3,4-difluorophenoxy)-4-methoxy-5-trifluoromethansulfonyl-6-[2,4-dichlorophenyl]pyrimidine (54 mg, 0.1 mmol) as described in Reference Example 17 and 4-methoxy-benzeneboronic acid (Lancaster, 16 mg, 0.11 mmol). HPLC/MS: m/e=488 (M+−1); Rt=4.62 min. 1H-NMR 500 MHz (CDCl3): δ 3.86 (s, 3H), 4.09 (s, 3H), 6.66 (m, 1H), 6.78 (m, 1H), 6.87 (dd, J=6 Hz, J=2 Hz, 2H), 7.08 (dd over m, J=6 Hz, J=2 Hz, 3H), 7.40 (d, J=1 Hz, 2H), 7.45 (d, J=2 Hz, 1H).

Provenance & Evidence