4-(Trifluoromethyl)phenylboronic acid → HCID 59753924, compound

HRID 750881Notes

Reaction equation

HRID 750881 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[O:5][C:6]1[N:11]=[C:10]([O:12][CH3:13])[C:9](S(C(F)(F)F)(=O)=O)=[C:8]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[Cl:28])[N:7]=1.[F:33][C:34]([F:45])([F:44])[C:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[O:5][C:6]1[N:11]=[C:10]([O:12][CH3:13])[C:9]([C:38]2[CH:39]=[CH:40][C:35]([C:34]([F:45])([F:44])[F:33])=[CH:36][CH:37]=2)=[C:8]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[Cl:28])[N:7]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 86601403HCID 86601403, compound

Product 1

HCID 59753924HCID 59753924, compound

Procedure

This derivative was prepared by the method described in Example 132 using 2-(3,4-difluorophenoxy)-4-methoxy-5-trifluoromethansulfonyl-6-[2,4-dichlorophenyl]pyrimidine (60 mg, 0.11 mmol) as described in Reference Example 17 and 4-trifluoromethylbenzeneboronic acid (Lancaster, 24 mg, 0.13 mmol HPLC Rt=4.76 min. 1H-NMR 500 MHz (CDCl3): 4.13 (s, 3H), 6.55 (m, 1H), 6.68 (m, 1H), 7.07 (q, J=10 Hz, 1H), 7.28 (m, 3H), (7.50 m, 3H), 7.61 (d, J=10 Hz, 2H).

Workup

  1. customThis derivative was prepared by the method

Sources & evidence

ORD record
ord-ef755d322bfd41a08795649d8bf3869d
Source dataset
uspto-grants-2008_07
Patent number
US07405221B2

Reaction notes

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