4-Methoxybenzohydrazide → 4-Methoxy-benzoic acid-(1-imino-propyl)-hydrazide

HRID 750889Notes

Reaction equation

HRID 750889 reaction equation
Cl.[C:2](N)(=[NH:5])[CH2:3][CH3:4].[CH3:7][O:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([NH:15][NH2:16])=[O:14])=[CH:11][CH:10]=1>>[NH:5]=[C:2]([N:15]([C:13](=[O:14])[C:12]1[CH:11]=[CH:10][C:9]([O:8][CH3:7])=[CH:18][CH:17]=1)[NH2:16])[CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 767924-MethoxybenzohydrazideHCID 12301253Propionimidamide hydrochloride

Product 1

HCID 684954834-Methoxy-benzoic acid-(1-imino-propyl)-hydrazideYield 150.7%

Procedure

Prepared from 4.90 g (45 mmol) propioamidine hydrochloride and 5.00 g (30 mmol) 4-methoxy-benzoic acid hydrazide analogously to the method described for intermediate product 1a). After the ethanol has been distilled off, 10.0 g crude product is obtained that is reacted without any further purification.

Workup

  1. distillationAfter the ethanol has been distilled off

Sources & evidence

ORD record
ord-faf1641fad884128a2f81ac4a3a62cf1
Source dataset
uspto-grants-2008_07
Patent number
US07405232B2

Reaction notes

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