1,4-Dioxane hydrochloride → (2S,2'S)-N,N'-(biphenyl-2,2'-diyl)dipyrrolidine-2-carboxamide

Participants

Reaction Steps

(2S,2′S)-tert-butyl-2,2′-(biphenyl-2,2′-diylbis(azanediyl))bis(oxomethylene)dipyrrolidine-1-carboxylate d (0.140 g, 0.24 mmol) was suspended in a solution of 4M HCl/dioxane and stirred at room temperature for 4 h until LCMS indicated complete deprotection. The reaction mixture was concentrated to give (2S,2′S)—N,N′-(biphenyl-2,2′-diyl)dipyrrolidine-2-carboxamide e (0.09 g, 100%). LC/MS: mw 378.47; M+H+=379.2.

Provenance & Evidence