N-[2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-phenyl]-methanesulphonamide → HCID 11329794, compound

HRID 750893Notes

Reaction equation

HRID 750893 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:21])[CH:16](OCC)O)=[CH:11][C:10]=1[NH:22][S:23]([CH3:26])(=[O:25])=[O:24])C1C=CC=CC=1.[O:27]1[C:31]2[CH:32]=[CH:33][C:34]([C:36]3[N:40]=[C:39]([CH3:41])[N:38]([CH2:42][CH2:43][C:44]([NH2:47])([CH3:46])[CH3:45])[N:37]=3)=[CH:35][C:30]=2[O:29][CH2:28]1>>[O:27]1[C:31]2[CH:32]=[CH:33][C:34]([C:36]3[N:40]=[C:39]([CH3:41])[N:38]([CH2:42][CH2:43][C:44]([NH:47][CH2:16][CH:15]([C:12]4[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([NH:22][S:23]([CH3:26])(=[O:24])=[O:25])[CH:11]=4)[OH:21])([CH3:45])[CH3:46])[N:37]=3)=[CH:35][C:30]=2[O:29][CH2:28]1

Participants

3

Reactant 2

HCID 10317570N-[2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-phenyl]-methanesulphonamideHCID 59754196HCID 59754196, compound

Product 1

HCID 11329794HCID 11329794, compound

Procedure

Analogously to the method described for Example 7, 379 mg (1 mmol) N-[2-benzyloxy-5-[2-ethoxy-2-hydroxy-acetyl)-phenyl]-methanesulphonamide and 288 mg (1 mmol) 3-(3-benzo[1,3]dioxol-5-yl-5-methyl-[1,2,4]triazol-1-yl)-1,1-dimethyl-propylamine are reacted with one another. The subsequent debenzylation yields the target compound.

Workup

  1. customare reacted with one another
  2. customThe subsequent debenzylation yields the target compound

Sources & evidence

ORD record
ord-4a9386722ec94bb28734ea9bfddd6211
Source dataset
uspto-grants-2008_07
Patent number
US07405232B2

Reaction notes

Loading…