HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(4-Nitrophenyl)piperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | 4-Piperidone hydrochloride | HCID 3084851 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-(4-Nitrophenyl)piperidin-4-one | HCID 3842562 | 80% |
Reaction Steps
The mixture of 4-piperidone hydrochloride (0.851 mol), triethylamine (1.70 mol), 4-fluoronitrobenzene (0.851 mol) in 800 ml chloroform was heated under reflux for 16 hours. The solvent was removed under vacuum and to the residue water (1 liter) was added and the precipitate was filtered to afford 4-[4-oxo-piperidin-1-yl]-nitrobenzene in 80% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405228B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-1001ed4fe9fc46c09dd1138e2981da30 |
| Source note | uspto-grants-2008_07 |