HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 750896Generated: October 30, 2026
Chlorotrimethylsilane → HCID 69313311, compound
https://huagongshe.com/reaction/750896
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(4-Nitrophenyl)piperidin-4-one | HCID 3842562 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69313311 | HCID 69313311 | 90% |
Reaction Steps
The mixture of 4-(4-oxo-Piperidin-1-yl)-nitrobenzene (126 mmol), triethylamine (630 mmol), trimethylsilylchloride (375.0 mmol) in dimethylformamide was heated at 70° C. for 24 h. The solvent was removed under vacuum and to the residual mass was extracted with the ethyl acetate water mixture. The combined organic layer was dried and after removal of the solvent afforded title compound as a solid in 90% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07405228B2 |
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| Source dataset | uspto-grants-2008_07 |
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| ORD ID | ord-9c2b24dc1c44476ea6eda9d9668762aa |
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| Source note | uspto-grants-2008_07 |
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