Methyl iodide → HCID 24885629, compound

Participants

Reaction Steps

The compound obtained in Example 9 (1 mmol) was treated with n-butyl lithium (1.6 M in hexane, 1.6 mmol), methyl iodide (2 mmol) in 10 ml tetrahydrofuran at −78° C. temperature. The reaction mixture was with ethyl acetate water mixture. The organic layer was evaporated to give a crude compound, which was chromatographed on a silica gel to give the titled compound in 44% yield.

Provenance & Evidence