HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (1-cyanoethyl)phosphonate → (S)-N-{3-[4-(4-(1-cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (1-cyanoethyl)phosphonate | HCID 282103 | — |
| Reactant | (S)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine | HCID 69315308 | — |
| Product | (S)-N-{3-[4-(4-(1-cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine | HCID 69315435 | 74% |
Reaction Steps
The compound was prepared by following the procedure of Example-1 and by using (S)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine and diethyl-(1-cyanoethyl)-phosphonate in 74% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405228B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-6f684710c0a748bfb0eae79346601052 |
| Source note | uspto-grants-2008_07 |