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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 750931Generated: October 25, 2026

Diethyl (1-cyanoethyl)phosphonate → (R)-{3-[4-(4-(1-Cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol

https://huagongshe.com/reaction/750931

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl (1-cyanoethyl)phosphonateHCID 282103—
Reactant(R)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcoholHCID 60133490—
Product(R)-{3-[4-(4-(1-Cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcoholHCID 6931519863%

Reaction Steps

The title compound was prepared by following the procedure of Example 1 and by using (R)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol and diethyl(1-cyanoethyl)-phosphonate in 63% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07405228B2
Source datasetuspto-grants-2008_07
ORD IDord-0bf5f29d86d548618b0491e97e281474
Source noteuspto-grants-2008_07