Potassium Iodide → HCID 11249576, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.11 g (0.49 mmol) 4-(4-[1,2,3]triazol-1-yl-butyl)-phenol and 0.10 g (0.30 mmol) cesium carbonate in 10 ml butanone was stirred at 60° C. for 30 min, then 0.15 g (0.49 mmol) 4-chloromethyl-2-[2-(4-trifluoromethanesulfinyl-phenyl)-vinyl]-thiazole and 0.08 g (0.49 mmol) potassium iodide were added and stirring at 60° C. continued for 3 days. After evaporation, 15 ml water was added and the mixture extracted with two portions of 15 ml ethyl acetate. The combined organic layers were washed with 1N sodium hydroxide and water, dried over sodium sulfate and evaporated to give, after purification on silica (ethyl acetate/heptane 1:1, then ethyl acetate) 90 mg (34%) 1-[4-(4-{2-[(E)-2-(4-trifluoromethanesulfinyl-phenyl)-vinyl]-thiazol-4-ylmethoxy}-phenyl)-butyl]-1H-[1,2,3]triazole as white crystals melting at 118-119° C.

Provenance & Evidence