Acetyl chloride → HCID 68954629, compound

Participants

Reaction Steps

N-(3-Hydroxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid (7.0 g, 20.0 mmol) was dissolved in 210 mL of MeOH and 2.8 g (36.0 mmol) of acetyl chloride was added. The material was warmed to reflux with stirring overnight. The solution was concentrated in vacuo and then diluted with 200 mL of DCM and washed with saturated NaHCO3, brine, dried (Na2SO4), and concentrated to give 6.85 g (84% yield) of the desired target.

Provenance & Evidence