2-(1,1-Dimethylprop-2-ynyloxy)-4-nitrobenzonitrile → 2,2-Dimethyl-5-nitro-2H-chromene-8-carbonitrile

Participants

Reaction Steps

A solution of compound 6A (270 mg, 1.17 mmol) in N,N-diethylaniline (1 mL) was heated to 185° C. for 3 h. After cooling to rt, the reaction mixture was chromatographed (silica gel) eluting with 0-50% EtOAc/hexane to afford the title compound (230 mg).

Provenance & Evidence