HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → (7R,7aS)-8-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)benzo[1,4]dioxane-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | (7R,7aS)-4-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-5,6,7,8-tetrahydronaphthalene-1-carbonitrile | HCID 9904811 | — |
| Reactant | N-(8-Bromobenzo[1,4]dioxan-5-yl)-acetamide | HCID 23269228 | — |
| Reactant | N-(4-Cyano-5,6,7,8-tetrahydronaphthalen-1-yl)-acetamide | HCID 68460315 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | (7R,7aS)-8-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)benzo[1,4]dioxane-5-carbonitrile | HCID 59754293 | — |
Reaction Steps
The title compound (32 mg) was prepared from compound 8D and isolated as a white solid by procedures analogous to those described in Example 2 (2C to 2F). mp196-197° C.; HPLC: 99% at 12.31 min (retention time) (CHIRALPAK® OD column 4.6×250 mm; 25% isopropanol in hexane over 30 min, 1 mL/min, UV detection at 220 nm); MS (ES) m/z 322 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405234B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-2fd20c4c61ed489b903099f942fd1365 |
| Source note | uspto-grants-2008_07 |