4-Amino-2-chloro-3-fluorobenzonitrile → 4-Isocyanato-3-fluoro-2-chlorobenzonitrile

HRID 751152Notes

Reaction equation

HRID 751152 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([Cl:10])[C:3]=1[F:11].N(C1C2CCCCC=2C(C#N)=CC=1)=[C:13]=[O:14]>>[N:1]([C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([Cl:10])[C:3]=1[F:11])=[C:13]=[O:14]

Participants

3

Reactant 2

HCID 534162084-Amino-2-chloro-3-fluorobenzonitrileHCID 597543044-Isocyanato-5,6,7,8-tetrahydronaphthalene-1-carbonitrile

Product 1

HCID 597542814-Isocyanato-3-fluoro-2-chlorobenzonitrile

Procedure

4-Isocyanato-3-fluoro-2-chlorobenzonitrile was prepared from 4-amino-3-fluoro-2-chlorobenzonitrile (73B) in a manner similar to that described in Example 2 for the preparation of 2E.

Sources & evidence

ORD record
ord-75b67ef5f8a64cdb93cbe1b0ae5bb3d7
Source dataset
uspto-grants-2008_07
Patent number
US07405234B2

Reaction notes

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