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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 751153생성일: 2026년 10월 25일

(2R,3R)-3-(tert-Butyl-dimethylsilanyloxy)-2-[(1R)-(2,2,2-trifluoro-1-hydroxyethyl)]pyrrolidine-1-carboxylic acid tert-butyl ester → (1S,7R,7aR)-2-Chloro-4-(7-hydroxy-1-trifluoromethyl-3-oxohexahydro-pyrrolo[1,2-c]imidazol-2-yl)-3-fluorobenzonitrile

https://huagongshe.com/reaction/751153

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참여 물질

역할이름HCID투입량
반응물(2R,3R)-3-(tert-Butyl-dimethylsilanyloxy)-2-[(1R)-(2,2,2-trifluoro-1-hydroxyethyl)]pyrrolidine-1-carboxylic acid tert-butyl esterHCID 16732286—
반응물4-Isocyanato-3-fluoro-2-chlorobenzonitrileHCID 59754281—
생성물(1S,7R,7aR)-2-Chloro-4-(7-hydroxy-1-trifluoromethyl-3-oxohexahydro-pyrrolo[1,2-c]imidazol-2-yl)-3-fluorobenzonitrileHCID 59754245—

반응 단계

The title compound was prepared from (2R,3R)-3-(tert-butyl-dimethylsilanyloxy)-2-[(1R)-(2,2,2-trifluoro-1-hydroxyethyl)]pyrrolidine-1-carboxylic acid tert-butyl ester (66A) and 2-chloro-4-isocyanato-3-fluorobenzonitrile (73C) following procedures analogous to those found in Example 72. LCMS: m/z 364 [M+H]+

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07405234B2
출처 데이터셋uspto-grants-2008_07
ORD IDord-89916a58f2f14c3f879b14cc6e41de26
출처 메모uspto-grants-2008_07