Lithium Hydroxide → HCID 11611416, compound

Participants

Reaction Steps

To a solution of {6-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid ethyl ester (30 mg, 67 μmol) in THF/methanol 2/1 (1.5 ml) was added 1 N aqueous LiOH solution (400 μl). The reaction mixture was stirred for 14 h at ambient temperature and concentrated under reduced pressure. The residue was dissolved in 1 N HCl/ice water 1/1 and ethyl acetate, the layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with ice water/brine 1/1, dried over sodium sulfate and the solvent was evaporated in vacuo to give the title compound (28 mg, 67 μmol, quant.) as brown crystals.

Provenance & Evidence