HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-pentynoate → 5-(4-Trifluoromethoxy-phenyl)-pent-4-ynoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-pentynoate | HCID 543061 | — |
| Reactant | 1-Iodo-4-(trifluoromethoxy)benzene | HCID 2777294 | — |
| Product | 5-(4-Trifluoromethoxy-phenyl)-pent-4-ynoic acid methyl ester | HCID 68821187 | — |
Reaction Steps
In analogy to the procedure described for example 8 a], pent-4-ynoic acid methyl ester (W. D. Wulff, S. J. McCallum, F. A. Kunng, J. Am. Chem. Soc. 1988, 110, 7419-7434) was reacted with 1-iodo-4-trifluoromethoxy-benzene in the presence of PdCl2(Ph3P)2 and cuprous iodide to give the title compound as brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405236B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-6f8b8e5d3ff44c82b8b592663c8fe2c6 |
| Source note | uspto-grants-2008_07 |