HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → {6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynoylamino]-indol-1-yl}-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Ethyl 2-(6-amino-1H-indol-1-yl)acetate | HCID 16731704 | — |
| Reactant | 4-Pentynoic acid, 5-[4-(trifluoromethoxy)phenyl]- | HCID 68822685 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | {6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynoylamino]-indol-1-yl}-acetic acid ethyl ester | HCID 68821712 | — |
Reaction Steps
In analogy to the procedure described in example 8 c], (6-amino-indol-1-yl)-acetic acid ethyl ester (WO 2003041714 A1) was reacted with 5-(4-trifluoromethoxy-phenyl)-pent-4-ynoic acid in the presence of 1-[3-(dimethylamino)-propyl]-3-ethylcarbodiimide hydrochloride and 4-(dimethylamino)pyridine to give the title compound as brown crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405236B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-00834225e95d4ba3ba6517c0b3e9d600 |
| Source note | uspto-grants-2008_07 |