HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (6-{Methyl-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynoyl]-amino}-indol-1-yl)-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | {6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynoylamino]-indol-1-yl}-acetic acid ethyl ester | HCID 68821712 | — |
| Product | (6-{Methyl-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynoyl]-amino}-indol-1-yl)-acetic acid | HCID 11676633 | — |
Reaction Steps
In analogy to the procedure described in example 8 d], {6-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynoylamino]-indol-1-yl}-acetic acid ethyl ester was reacted with methyl iodide in the presence of sodium hydride to give the title compound as brown liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405236B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-0350212c107947f2aca81eb31eabc478 |
| Source note | uspto-grants-2008_07 |