HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → [rac]-2-{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl]-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester | HCID 11616756 | — |
| Reactant | [Rac]-2-(6-hydroxy-indol-1-yl)-propionic acid ethyl ester | HCID 68826438 | — |
| Product | [rac]-2-{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl]-propionic acid ethyl ester | HCID 68824015 | — |
Reaction Steps
In analogy to the procedure described in example 11 c], [rac]-2-(6-hydroxy-indol-1-yl)-propionic acid ethyl ester (GB 2253848 A1) was reacted with methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester (example 9 a]) in the presence of cesium carbonate and potassium iodide to give the title compound as colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405236B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-244fb64dfeee4a8aa06781a10a19884e |
| Source note | uspto-grants-2008_07 |