Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 751220Generated: October 25, 2026

1-Iodo-4-(trifluoromethoxy)benzene → 2-(1H-Indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide

https://huagongshe.com/reaction/751220

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Iodo-4-(trifluoromethoxy)benzeneHCID 2777294—
Reactant2-(1H-Indol-6-yl)-N-prop-2-ynyl-acetamideHCID 86095505—
Product2-(1H-Indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamideHCID 68825664—

Reaction Steps

In analogy to the procedure described for example 8 a], 2-(1H-indol-6-yl)-N-prop-2-ynyl-acetamide was reacted with 4-(trifluoromethoxy)-iodobenzene in the presence of PdCl2(Ph3P)2 and cuprous iodide to give the title compound as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07405236B2
Source datasetuspto-grants-2008_07
ORD IDord-2d278a71bb944401bfba164c31f4be3d
Source noteuspto-grants-2008_07