HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → 5-(4-Trifluoromethyl-phenyl)-pent-4-ynoic acid (1H-indol-6-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2-(1H-indol-6-yl)ethan-1-amine | HCID 17221100 | — |
| Reactant | HCID 68824010 | HCID 68824010 | — |
| Product | 5-(4-Trifluoromethyl-phenyl)-pent-4-ynoic acid (1H-indol-6-ylmethyl)-amide | HCID 86095529 | — |
Reaction Steps
In analogy to the procedure described for example 13 a], 5-(4-trifluoromethyl-phenyl)-pent-4-ynoic acid was reacted with 6-aminoethyl-1H-indole in the presence of 1-hydroxybenzotriazole, 4-ethylmorpholine and 1-[3-(dimethylamino)-propyl]-3-ethylcarbodiimide hydrochloride to give the title compound as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405236B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-beced779e0224c3ba3ae5545346f4028 |
| Source note | uspto-grants-2008_07 |