HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → [6-({Methyl-[5-(4-trifluoromethyl-phenyl)-pent-4-ynoyl]-amino}-methyl)-indol-1-yl]-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (6-{[5-(4-Trifluoromethyl-phenyl)-pent-4-ynoylamino]-methyl}-indol-1-yl)-acetic acid ethyl ester | HCID 68826130 | — |
| Product | [6-({Methyl-[5-(4-trifluoromethyl-phenyl)-pent-4-ynoyl]-amino}-methyl)-indol-1-yl]-acetic acid | HCID 67012681 | — |
Reaction Steps
In analogy to the procedure described in example 8 d], (6-{[5-(4-trifluoromethyl-phenyl)-pent-4-ynoylamino]-methyl}-indol-1-yl)-acetic acid ethyl ester was reacted with methyl iodide in the presence of sodium hydride to give the title compound as yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405236B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-b61c8bb2c4294e06b48341d98babc689 |
| Source note | uspto-grants-2008_07 |