1-Iodo-4-(trifluoromethoxy)benzene → [3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-carbamic acid tert-butyl ester

HRID 751231Notes

Reaction equation

HRID 751231 reaction equation
[CH2:1]([NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8])[C:2]#[CH:3].I[C:13]1[CH:18]=[CH:17][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:15][CH:14]=1>>[C:7]([O:6][C:5](=[O:11])[NH:4][CH2:1][C:2]#[C:3][C:13]1[CH:14]=[CH:15][C:16]([O:19][C:20]([F:21])([F:22])[F:23])=[CH:17][CH:18]=1)([CH3:8])([CH3:10])[CH3:9]

Participants

3

Reactant 2

HCID 27772941-Iodo-4-(trifluoromethoxy)benzeneHCID 11073648tert-butyl N-(prop-2-yn-1-yl)carbamate

Product 1

HCID 68823297[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-carbamic acid tert-butyl ester

Procedure

In analogy to the procedure described for example 8 a], tert-butyl 2-propynylcarbamate was reacted with 1-iodo-4-trifluoromethoxy-benzene in the presence of PdCl2(Ph3P)2 and cuprous iodide to give the title compound as yellow crystals.

Sources & evidence

ORD record
ord-e37c9f6cbb674dd78da8e493fbfd961b
Source dataset
uspto-grants-2008_07
Patent number
US07405236B2

Reaction notes

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