HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → 2-(1H-Indol-6-yl)-N-methyl-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1H-Indole-6-acetic acid | HCID 14882503 | — |
| Reactant | 2-Propyn-1-amine, N-methyl-3-[4-(trifluoromethoxy)phenyl]- | HCID 68823910 | — |
| Product | 2-(1H-Indol-6-yl)-N-methyl-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide | HCID 68821722 | — |
Reaction Steps
In analogy to the procedure described for example 13 a], (1H-indol-6-yl)-acetic acid (U.S. Pat. No. 4,894,386 A) was reacted with methyl-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-amine in the presence of 1-hydroxybenzotriazole, 4-ethylmorpholine and 1-[3-(dimethylamino)-propyl]-3-ethylcarbodiimide hydrochloride to give the title compound as orange oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405236B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-4cc0068907b6456aa7008e58d55fe240 |
| Source note | uspto-grants-2008_07 |