Carbon Dioxide → HCID 68826125, compound

Participants

Reaction Steps

DIBAL-H (1.46 ml, 1.75 mmol; 1.2 M solution in toluene) was added dropwise within 15 min to a dry ice cooled (−30° C.) solution of 6-(4-trifluoromethoxy-phenyl)-hex-5-yn-2-one (0.23 g, 0.88 mmol) in THF (4 ml). The reaction was warmed to 0° C. over a time period of 1 h 10 min and neutralized with aqueous 10% KHSO4 solution. The mixture was extracted with ether (three times), the combined organic layers were washed with aqueous 10% NaCl solution, dried (Na2SO4) and evaporated to give 0.24 g (quant.) of the title compound as light brown oil.

Provenance & Evidence