反应详情

To a solution of Intermediate 3-2 (4.21 g) and TEA (2.0 g) in DCM (50 mL) was added benzoyl chloride (2.11 g) slowly. After stirring at room temperature for 1 hour and then the reaction was quenched with saturated sodium bicarbonate. The organic phase was dried over sodium sulfate and evaporated to dryness. Purification was achieved by chromatography on an ISCO column (RediSep 12, gradient elution with 10% to 70% EtOAc/Hex providing pure Intermediate 3-3 (2.82 g, 49% yield for the three steps).

1. customthe reaction was quenched with saturated sodium bicarbonate
2. dry with materialThe organic phase was dried over sodium sulfate
3. customevaporated to dryness
4. customPurification
5. washRediSep 12, gradient elution with 10% to 70% EtOAc/Hex