HCID 10027123, compound → HCID 11740079, compound

Participants

Reaction Steps

Heat a solution of (6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1-[3-(tetrahydro-pyran-2-yloxy)-propyl]-1H-benzoimidazole (Example 54; 368 mg mg, 0.8 mmol) in 4:2:1 acetic acid/tetrahydrofuran/water (20 mL) to 80° C. for 18 h. Remove the solvent in vacuo and dissolve the residue in excess 3:1 chloroform/isopropyl alcohol. Wash the organic layer with saturated sodium bicarbonate, dry over sodium sulfate, filter, and concentrate in vacuo. Purify the residue by column chromatography on silica gel eluting with dichloromethane to 10% methanol/90% dichloromethane to give the desired product as a white solid (225 mg, 75%). MS ES+ m/e 374.3 (M+1).

Provenance & Evidence