Dimethylamine → HCID 44408672, compound

Participants

Reaction Conditions

Reaction Steps

Combine methanesulfonic acid methanesulfonic acid 3-[6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-benzoimidazol-1-yl]-propyl ester (Example 57a; 22 mg, 0.048 mmol) with 2M dimethylamine in THF (2 mL). Heat the mixture at 80° C. for 30 min. Cool, evaporate the excess amine, and purify the crude product with FCC to give the title compound (18.5 mg, 95%). MS m/e 401.3 (M+1).

Provenance & Evidence