HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-(1-phenylsulfonyl)indole → 1-Benzenesulfonyl-3-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-(1-phenylsulfonyl)indole | HCID 2776215 | — |
| Reactant | (2-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-boronic acid | HCID 59710031 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzenesulfonyl-3-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1H-indole | HCID 58611941 | — |
Reaction Steps
The titled intermediate was made via Preparation 33 (General Suzuki Coupling Method D) from 1-benzene-sulfonyl-3-bromo-1H-indole (Maybridge) and 2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-boronic acid (Preparation 5). MS (ESI) m/e 441 (M+1). TLC (SiO2): Rf0.5 (1:1 methylene chloride/[80:18:2 chloroform/methanol/concentrated aqueous ammonium hydroxide]).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405299B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-132ac5ae2afa4885a845977a0d6a9781 |
| Source note | uspto-grants-2008_07 |