2-chloro-1-phenyl-1H-indole-3-carbaldehyde → HCID 11186641, compound

HRID 751339Notes

Reaction equation

HRID 751339 reaction equation
Cl[C:2]1[N:3]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.C(O[C:24]([N:26]1[CH2:31][CH2:30][CH:29]([NH:32]C)[CH2:28][CH2:27]1)=O)(C)(C)C>>[CH3:24][N:26]1[CH2:31][CH2:30][CH:29]([NH:32][C:2]2[N:3]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 3147932-chloro-1-phenyl-1H-indole-3-carbaldehydeHCID 15380702tert-Butyl 4-(methylamino)piperidine-1-carboxylate

Product 1

HCID 11186641HCID 11186641, compoundYield 18%

Procedure

2-Chloro-1-phenyl-1H-indole-3-carboxaldehyde is reacted with 4-methylamino-piperidine-1-carboxylic acid tert-butyl ester as described in Example 2 to give the title compound (18% yield). LC-RT 2.20 min.; MS 334 (M+H).

Sources & evidence

ORD record
ord-35d101d23f104546988d81d1fc49b11e
Source dataset
uspto-grants-2008_07
Patent number
US07405300B2

Reaction notes

Loading…