HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-1-phenyl-1H-indole-3-carbaldehyde → 4-(3-formyl-1-phenyl-1H-indole-2-yl)-piperazine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-1-phenyl-1H-indole-3-carbaldehyde | HCID 314793 | — |
| Reactant | Methyl Piperazine-2-carboxylate | HCID 2760426 | — |
| Product | 4-(3-formyl-1-phenyl-1H-indole-2-yl)-piperazine-2-carboxylic acid methyl ester | HCID 11739991 | 9% |
Reaction Steps
2-Chloro-1-phenyl-1H-indole-3-carboxaldehyde is reacted with piperazine-2-carboxylic acid methyl ester as described in Example 1 to afford 4-(3-formyl-1-phenyl-1H-indole-2-yl)-piperazine-2-carboxylic acid methyl ester (9% yield) as a yellow solid. LC/MS: MS 364 (M+H); RT 2.54 min; NMR (CDCl3): 10.29 (1H, s), 8.26 (1H, d), 7.07-7.65 (m, buried), 6.98 (1H, d), 3.60-4.10 (4H, m), 2.60-3.55 (6H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405300B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-729c173c43c04ae48ce61ac5cde8916d |
| Source note | uspto-grants-2008_07 |