HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Biphenyl-4-yl-boronic acid → 1-biphenyl-4-yl-2-chloro-1H-indole-3-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Biphenyl-4-yl-boronic acid | HCID 151253 | — |
| Reactant | 2-chloro-1H-indole-3-carbaldehyde | HCID 314791 | — |
| Product | 1-biphenyl-4-yl-2-chloro-1H-indole-3-carboxaldehyde | HCID 86035896 | 52% |
Reaction Steps
2-Chloro-1H-indole-3-carboxaldehyde is reacted with 4-biphenylboronic acid as described in Step 1 of Example 29 to afford 1-biphenyl-4-yl-2-chloro-1H-indole-3-carboxaldehyde (52% yield) as a yellow solid. ESI/MS 332 (M+H), RT 4.14 min; NMR 10.15 (1H, s); 8.23 (1H, d, J=9 Hz); 7.99 (2H, d, J=9 Hz); 7.82 (2H, d, J=9 Hz); 7.69 (7H, m); 7.54 (1H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405300B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-0b520764105b4f5789f3d85c32b82025 |
| Source note | uspto-grants-2008_07 |